For the person with the micro-bladder I would always recommend the aisle. There have been enough in-flight skirmishes reported over bad etiquette on planes, and waking up the aisle person 4 times during the night would be considered bad etiquette. Stinky feet, bad. Yelling at the mother with the crying baby, bad. Is it that suddenly people don’t know how to fly or are these cases of people who have actually never flown before?
As the person who rarely ever gets the window seat, I decided this was going to be the trip. If you ever make the trip from east to west of Canada I recommend taking a day flight so you can actually look out the window and see the Rockies. Otherwise the window seat just becomes something that you can lean on and it won’t complain.